Di kehidupan modern, Rizal yang bertubuh 100 kg tanpa sengaja menikahi Gempita, sang CEO wanita yang galak dan berkuasa. Serangkaian kesialan beruntun mengakibatkan Gempita menjadi cacat. Murka besar, Gempita menghukum buang Rizal ke desa terpencil! Namun, Fajar yang mengetahui pernikahan Rizal dan Gempita, datang bersama pembunuh bayaran untuk menyingkirkan Rizal. Di saat genting, jiwa Tabib Agung dari zaman kuno menyatu ke dalam tubuh Rizal masa kini. Dengan gerakan cepat, dia mengatasi Fajar dan para pembunuhnya. Untuk bertahan hidup, Rizal memulai profesi barunya: membuka praktik pengobatan tradisional. Namun, siapa sangka, sebulan kemudian, kejutan terbesar datang: Gempita mengandung dan melahirkan kembar lima...
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